Correspondence: Reply to ‘Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα’

Correspondence: Reply to ‘Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα'

cells (a) TaqMan qPCR analysis of BMAL1 and REV-ERBα transcripts normalized to GAPDH from Figure 1b at 24 and 36 hours after synchronization (n=3). (b) Overexpressed MYC correlates with reduced expression of BMAL1 and CLOCK, while REV-ERBα levels are different in two cell clones. Western blot analysis of indicated proteins in synchronized U2OS t-rex tetO-MYC cells treated with doxycycline to in...

Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα

Rev-erbα Regulates Tshb Circadian Rhythm 1 Circadian Regulation of Tshb Expression by Rev-erbα (NR1D1) and NCOR1

Thyroid hormones (TH) are critical for development, growth, and metabolism. Circulating TH levels are tightly regulated by thyroid stimulating hormone (TSH) secretion within the hypothalamic-pituitary-thyroid (HPT) axis. While circadian TSH secretion has been well documented, the mechanism of this observation remains unclear. Recently, the nuclear corepressor, NCOR1, has been postulated to regu...

A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.

Disruption of the circadian rhythm is a contributory factor to clinical and pathophysiological conditions, including cancer, the metabolic syndrome, and inflammation. Chronic and systemic inflammation are a potential trigger of type 2 diabetes and cardiovascular disease and are caused by the infiltration of large numbers of inflammatory macrophages into tissue. Although recent studies identifie...

The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet.

Disturbances of circadian rhythms have been associated with obesity and type 2 diabetes. The nuclear receptor Rev-erbα was suggested to link circadian rhythms and metabolism in peripheral tissues. The aim of the present study was to dissect the role of this clock gene in the pancreatic β-cell function and to analyze whether its expression is modulated by leptin and diet-induced obesity. To addr...